Consistent with lower levels of intrahepatic viral RNA in both eHAV- and HAV-infected Tim1−/−Ifnar1−/− versus Ifnar1−/− animals, serum ALT activities were also lower in Tim1−/−Ifnar1−/− mice 7 and 14 days after infection (Fig. 4D). The gene discussed is HAVCR1; the disease is infection.