To determine whether the murine ortholog of TIM1 plays a role in hepatovirus pathogenesis in this animal model, we compared infections in Tim1−/−Ifnar1−/− versus single-knockout Ifnar1−/− mice inoculated intravenously with fifth murine passage HM175 virus recovered from the liver of an infected Mavs−/− mouse (Fig. 3). Here, MAVS is linked to infection.