Liver injury in the acute phase of the infection in Ifnar1−/− mice is marked by elevation of serum alanine aminotransferase (ALT) activity and due to mitochondrial antiviral signaling protein (MAVS)- and interferon regulatory factor 3 (IRF3)/IRF7-dependent, but interferon-independent apoptotic death of infected hepatocytes. The gene discussed is GPT; the disease is infection.