FAT1 and Nephropathy: For example, the discovery of an association between variation in FAT1 and a human phenotype of steroid-resistant nephropathy with neurologic involvement benefitted from studies in zebrafish and mice, demonstrating that loss of Fat1 leads to abnormal podocyte and brain development (Ciani et al. 2003; Skouloudaki et al. 2009; Gee et al. 2016).