IFNA1 and infection: In contrast to our expectations, Nestin-Cre+ IFN-γR2flox/flox mice were as susceptible to ECM during P. berghei ANKA infection as littermate Cre− control mice, with all Nestin-Cre+ IFN-γR2flox/flox mice developing late-stage ECM (20/20) and, in experiments where survival was specifically assessed, succumbing to infection on day 7 of infection (10/10) (Fig. 5B to D).