Interestingly, although the numbers of intracerebral CD8+ T cells were significantly decreased in infected globally IFN-γR2−/− mice compared with the numbers in WT mice on day 7 of infection, potentially contributing to the reduced inflammatory landscape in the brains of globally IFN-γR2−/− mice, the numbers of intracerebral CD8+ T cells were comparable in infected VAV-Cre+ IFN-γR2flox/flox mice and WT mice (Fig. 3F). This evidence concerns the gene CD8A and infection.