Although causative CNVs in these genes are expected to be rare, they have long remained uninvestigated because MLPA methods are either not available or not applied for genes outside the LDLR. Extending CNV analysis to all such FH-associated genes furthers our ability to account for all genetic abnormalities capable of explaining FH cases; this, in turn, further decreases false-negative findings. The gene discussed is LDLR; the disease is familial hyperaldosteronism.