According to the biochemical remission criteria recommended by the Chinese diagnostic and treatment guidelines for acromegaly [17, 18], the postoperative GH (100% vs. 62.1%) and IGF-1 (60% vs. 35.7%) remission rates in the patients with microadenoma who received preoperative SSAs treatment were higher compared with those in the patients who underwent surgery directly. This evidence concerns the gene IGF1 and acromegaly.