It was found that expression levels of ERp29 in tumor specimens were negatively correlated with the PI3K/Akt/GSK3β and Akt-mTOR signaling pathway-activated gene signatures and positively correlated with the PI3K/Akt/GSK3β and Akt-mTOR signaling pathway suppressed gene signatures (Fig. 5a and b, left panels). The gene discussed is GSK3B; the disease is neoplasm.