Ad5/MK-infected TE-10, TE-11 and YES-4, and Ad5/Sur-infected YES-4 and YES-6 cells in esophageal carcinoma, and Ad5/MK-infected NCI-H2452, NCI-H226 and NCI-H28 cells, Ad5/Sur-infected NCH-226 cells and Ad5/COX-2-infected NCI-H2452 cells in mesothelioma, achieved greater cytotoxicity than corresponding AdF35 vectors. This evidence concerns the gene PTGS2 and mesothelioma.