Using PSA-NCAM, we observed more numerous marked cells in all ALS cases than in controls: 6.5 ± 2.51 cells/500 μm2 in controls vs 19.78 ± 1.63 cells/500 μm2 in the ALS total (p < 0.01). This evidence concerns the gene NCAM1 and amyotrophic lateral sclerosis.