Fibril deposition may occur in any organ, and its presence may be diffuse or mimic neoplastic diseases; however, the osteoarticular system is almost invariably involved, due to the high affinity of beta 2 microglobulin for collagen and dialysis related amyloidosis is the main cause of carpal tunnel syndrome and scapula–humeral periarthritis in dialysis patients. Here, B2M is linked to amyloidosis.