DDN and tuberculosis: Notably, the M. tuberculosis F420-deficient Ddn mutants defective in the formation of dezaflavin were found to be hypersensitive to INH, clofazimine and moxifloxacin thus proposing that the inhibitors that can inhibit Ddn or dezaflavin biosynthesis could synergize with the existing anti-TB drugs, as observed in this study also.