INHA and tuberculosis: VLS involves flexible-ligand docking into the pocket using the consensual approach among DOCK and Vina, which has also been successful in identifying ligands for several mycobacterial targets such as PknG (Rv1827), InhA (Rv1484), MtCM (Rv1885c), MurE (Rv2158c), DHQase (Rv2537c), L-AlaDH (Rv2780), UMPK (Rv2883c), EthR (Rv3855) [7,8,38–43] etc. In addition, the TB structural genomics consortium (TBSGC, http://www.webtb.org) determines the 3D structures of proteins from M. tuberculosis for rational structure-based drug designing [44].