Many of M. tuberculosis protein structures determined by TBSGC are associated with the metabolic pathways and are suggested as potential attractive anti-TB drug targets, which include structural studies on urease (Rv1848), chorismate-utilizing enzymes, arginine biosynthesis enzymes, crotonase, malate synthase (Rv1837c) and phosphoenolpyruvate carboxykinase (Rv0211), etc. [44–47]. This evidence concerns the gene CLYBL and tuberculosis.