We further show that DUSP6 deficiency has limited effects on the regulation of systemic energy homeostasis, but impairs glucose homeostasis in adult mice; these data stand in contrast to earlier reports which suggest protection from DIO and glucose intolerance in the absence of DUSP6, potentially mediated via alterations in the gut microbiome [23,40,53]. Here, DUSP6 is linked to Glucose intolerance.