PPARA and signet ring cell carcinoma: We analyzed the effects of the RXR pan-agonist bexarotene and the PPAR pan-agonist bezafibrate on the expression levels of the target genes, by using the oligodendrocyte cell line OLP6—derived from the ventrolateral region of the suprachiasmatic nucleus (rat neuronal cell line)49—and GABA-containing KATO-III cells derived from human stomach cancer cells (signet ring cell carcinoma).50 Bexarotene treatment increased the expression levels of the oligodendrocyte-related genes Olig2, Cldn11, Mal and Mbp-long in OLP6 cells (Figure 3a).