The most frequent and T-ALL-specific ABL1 rearrangement is NUP214-ABL1 episomal amplification (6% cases), which was described in T-ALL cell lines, as well as in adult and pediatric patients associated with TLX1 or TLX3 expression and CDKN2A deletion [32,160,161]. Here, TLX3 is linked to acute lymphoblastic leukemia.