NOTCH1, which is mutated in half of T-ALL cases (see Section 5.1), can activate NF-κB pathway in T-ALL cell lines and in the intracellular NOTCH1 (ICN1)-induced mouse model, either transcriptionally, promoting RelB and p52 expression, or indirectly via IKK complex activation [177]. This evidence concerns the gene RELB and acute lymphoblastic leukemia.