Conversely, interleukin 7 receptor/Janus kinase/signal transducer and activator of transcription (IL-7R/JAK/STAT) signaling pathway or rat sarcoma viral oncogene homolog (RAS) mutations are frequently observed in immature T-ALL cases or TLX1/TLX3+ and HOXA+ cases. This evidence concerns the gene TLX1 and acute lymphoblastic leukemia.