In addition, mutations and deletions in tumor suppressor genes such as Wilms Tumor 1 (WT1), Lymphoid Enhancer Binding Factor 1 (LEF1), ETS Variant 6 (ETV6), B-Cell CLL/Lymphoma 11B (BCL11B), Runt Related Transcription Factor 1 (RUNX1) and GATA Binding Protein 3 (GATA3) contribute to the overall transcriptional deregulation of T-ALL, extensively reviewed in [5]. The gene discussed is LEF1; the disease is acute lymphoblastic leukemia.