EML4 and non-small cell lung carcinoma: To date, studies of EML4-ALK oncogenic signaling pathways have utilized cell lines derived from NSCLC patients or recombinant model cell lines expressing variant EML4-ALK fusions: for example, H3122 cells express EML4-ALK variant 1, whilst the H2228 cell line expresses variant 3a/b [32].