Accordingly, in ALS patients, the number of Tregs decreased in blood and spinal cord tissues accompanied by reduced expression of FoxP3, transforming growth factor-β, IL-4 and GATA binding protein 3 (Gata-3) at the rapidly progressive stage, and the number of Tregs was inversely correlated with the progression rates and severity (92, 93). The gene discussed is IL4; the disease is amyotrophic lateral sclerosis.