Among these was a unique inflammation-related gene expression profile, including IL-1β, IL-8, FOSB, CXCL1, and CXCL2, suggesting ALS monocytes were skewed toward a proinflammatory state in the peripheral circulation, which might play a role in rapidly progressing ALS (104). The gene discussed is CXCL8; the disease is amyotrophic lateral sclerosis.