CCL2 and colitis: This statement was further validated using Mcp1 knock-out mice (Mcp1−/−), where it has been observed that dinitrobenzene sulfonic acid-induced colitis in Mcp1−/− mice resulted in downregulation of colonic inflammation compared to their WT counterparts, which were associated with a lower number of classical macrophages and CD3+ cells in their colon when compared to WT colitic mice (88).