CD4 and tuberculosis: Interestingly, in this analysis, there were only two statistically significant correlations between Mtb-specific CD4+ populations and TB manifestations, i.e., the proportion of TNF-α+IFN-γ+IL-2+ CD4+ cells correlated positively with pulmonary destruction (p = 0.008) and the numbers of TNF-α−IFNg+IL-2+ CD4+ cells correlated negatively with bacteria excretion (p = 0.003).