SOD1 and amyotrophic lateral sclerosis: We find that while the protein levels of LC3B-II (Figure 5A) and SQSTM1/p62 (Figure 5B) are confirmed to be both increased at end stage in vehicle-treated SOD1-G93A mice with respect to WT, in A-804598-treated ALS mice with respect to vehicle, the LC3B-II protein content appears unmodified, while SQSTM1/p62 is inhibited to basal levels (Figures 5A,B).