The persistent stimulation of P2X7 causing autophagic flux inhibition in SOD1-G93A microglia in vitro is instead perhaps resembling what occurs during the symptomatic phase of the disease, when the pharmacological inhibition of P2X7 exerts beneficial effects on ALS progression (Apolloni et al., 2014; Sluyter et al., 2017). This evidence concerns the gene P2RX7 and amyotrophic lateral sclerosis.