We reviewed the functional properties of the driver nodes found to have the highest impact in controlling the essential proteins; they are ERBB2, SRC, PDPK1, PRKDC, mTOR for breast cancer, ERBB2, AKT1, GSK3B, ABL1 in pancreatic cancer, and RET in ovarian cancer. Here, PRKDC is linked to familial pancreatic carcinoma.