We reviewed the functional properties of the driver nodes found to have the highest impact in controlling the essential proteins; they are ERBB2, SRC, PDPK1, PRKDC, mTOR for breast cancer, ERBB2, AKT1, GSK3B, ABL1 in pancreatic cancer, and RET in ovarian cancer. This evidence concerns the gene PDPK1 and familial pancreatic carcinoma.