One of them is ERBB2, which controls five essential proteins in breast cancer (CDK1, CDC27, CDC7, SH3RF1, APLP2) and four essential proteins in pancreatic cancer (CNSK1E, MST1R, MAML1, ADAM17); Fig. 4 and Table 4. This evidence concerns the gene SH3RF1 and familial pancreatic carcinoma.