MYC and hepatocellular carcinoma: In the present study, we also found that the Myc model has a mild sex disparity in liver tumorigenesis and this may be due to a slower progression of the liver tumor in the Myc model; for example, histologically diagnosed HCC could be induced in the kras and xmrk models within one week of oncogene activation while it may takes 4 months to develop HCC under a high dose of induction in the Myc model17, 18, 34.