To validate our findings in an additional and independent system, we generated and characterized six other EGFR-TKI-resistant cell lines derived from the 11–18 NSCLC cell line, which harbors the other major EGFR-TKI-sensitizing EGFR mutation observed in NSCLC patients, EGFR L858R. This evidence concerns the gene EGFR and non-small cell lung carcinoma.