In addition, the combination of a PIK3-mTOR inhibitor with a MEK inhibitor has been reported to induce apoptosis in EGFR-TKI naïve EGFR-mutant NSCLC cell lines and xenografts, although the combination of an Akt and a MEK inhibitor failed to have this effect in this TKI-naive context32. This evidence concerns the gene EGFR and non-small cell lung carcinoma.