SIRT6 and focal segmental glomerulosclerosis: Considering that Sirt6 is a highly specific deacetylase that targets H3K9 for the regulation of gene expression by modifying chromatin structure7, 8, we then measured the levels of H3K9 acetylation (H3K9ac) under pathological conditions and found that the H3K9ac levels were significantly increased in renal biopsies from patients with DN and FSGS by IHC staining (Fig. 6a).