ADR-treated Cre+/Sirt6fl/fl mice exhibited significant increases in urinary albumin excretion (Fig. 8a), glomerulosclerosis (Fig. 8b) and podocyte injury (Fig. 8c), and marked decreases in the levels of nephrin and podocin (Fig. 8d) compared with the ADR-treated Cre+/Sirt6+/+ mice. Here, NPHS2 is linked to glomerulosclerosis.