SIRT6 and liver dysplastic nodule: In this study, we found that Cre+/Sirt6fl/fl diabetic mice exhibited a marked increase in the level of uPAR as compared with the Cre+/Sirt6+/+ diabetic mice, indicating that Sirt6 may be one of the critical components that links uPAR to podocyte injury in the pathogenesis of DN.