We also found that other renal parenchymal cells including rat glomerular mesangial cells, rat glomerular endothelial cells, and human tubule epithelial cells (HK-2) had different expression patterns of Sirt6 in response to hyperglycemia (Supplementary Fig. 2) or ADR (Supplementary Fig. 3). Here, SIRT6 is linked to Hyperglycemia.