Vgll3 as a new partner of ets1 was unexpected and is very challenging as ets1 is also a proto-oncogene and VGLL3 has been proposed to play a role in tumor progression (Antonescu et al., 2011; Cody et al., 2007, 2009; Gambaro et al., 2013; Hallor et al., 2009; Helias-Rodzewicz et al., 2010). The gene discussed is VGLL3; the disease is neoplasm.