Similar results were obtained using two distinct clones of MLL-ENL AML transplanted in WT or Nos3-KO recipient mice, showing significantly reduced disease penetrance (Figure S6A, bottom), reduced leukemic engraftment in the BM and spleen (Figures S6B and S6C), and amelioration of the anemic phenotype caused by AML (Figure S6D). Here, KMT2A is linked to acute myeloid leukemia.