NOX4 and acute myeloid leukemia: Interestingly, the NOX4-NOS3 axis, already reported previously to act in response to stress induced by hypoxic conditions (Craige et al., 2011, Drummond et al., 2000, Mittal et al., 2007, Thomas et al., 2002, Zhang et al., 2008), has a major role in orchestrating the AML-induced vascular leakiness.