To achieve this, and mimic the competition between AML cells and normal HSCs into the BM niche, we injected simultaneously normal human CB-derived HSPCs and AML patient-derived cells intravenously into non-irradiated NBSGW mice (McIntosh et al., 2015) and monitored the normal versus malignant engraftment in the presence or absence of long-term NOS inhibitors (Figure 7L). Here, NOS2 is linked to acute myeloid leukemia.