In the BM of AML xenografts, the residual murine HSC displayed higher levels of ROS (Figure 7A) and were mobilized to the periphery, as shown by increased SLAM+ cells in the blood of mice with AML xenografts compared with those without, as well as a reduced proportion of HSC in the BM (Figures 7B and 7C). This evidence concerns the gene SLAMF1 and acute myeloid leukemia.