Interestingly, the expression of adhesion molecules changed dramatically upon AML engraftment, with upregulation of integrins associated with Fak pathway activation in ECs (Figure S4B) inducing migration, growth, and survival of newly forming vessels during angiogenesis (Muether et al., 2007, Stenzel et al., 2011, Weis and Cheresh, 2011), as well as initiation of VEGF-mediated vascular permeability (Chen et al., 2012, Eliceiri et al., 2002, Rodrigues and Granger, 2015). Here, VEGFA is linked to acute myeloid leukemia.