Indeed, many reports showed that constitutive activation of STAT3 is frequently detected in primary human colorectal carcinoma (Kusaba et al., 2005; Corvinus et al., 2005) and contributes to invasion, survival, and growth of colorectal cancer cells (Tsareva et al., 2007; Lin et al., 2005). The gene discussed is STAT3; the disease is colorectal cancer.