DUX4 and Facioscapulohumeral dystrophy: The novelty of these findings highlight the differences between the screens described here and those performed by others, who have used exogenous DUX4-mediated cytotoxicity in non-FSHD cells to identify broad inhibitors and mediators of cell death pathways [16, 22, 28], whereas our efforts uncovered specific regulators of the D4Z4 array that potentially provide more precise ways to disrupt FSHD pathogenesis.