LRP6 and neoplasm: The in vivo tumor growth capacity in subcutaneous implantation nude mouse models of MHCC-97H-LRP6-sh cells was also significantly diminished compared to the MHCC-97H-Mock cells (0.72 ± 0.18 g vs. 1.54 ± 0.32 g, p = 0.0388; Fig. 4d).