LRP6 and hepatocellular carcinoma: To investigate the effect of CCN2 on Wnt signaling, we treated HCC cells with recombinant CCN2, and found that CCN2 was able to activate Wnt signaling with concomitant upregulation of LRP6, phosphorylated LRP6, and β-catenin, but decrease the phosphorylation level of β-catenin.