The multivariate Cox proportional hazards model revealed that overexpression of CCN2 (p = 0.002; p = 0.018) and LRP6 (p = 0.006; p = 0.014), vascular invasion (p = 0.019; p = 0.041), and tumor size (p = 0.013; p = 0.006) were independent prognostic indicators for OS and CCR of HCC patients; and AFP level (p = 0.039) was independent risk factor for the CCR of HCC patients. The gene discussed is LRP6; the disease is hepatocellular carcinoma.