CCN2 and neoplasm: Interestingly, LMWH alone could inhibit the in vivo tumor growth of MHCC97H cells (with high CCN2 expression) compared to the controls (2.42 ± 0.14 vs. 1.94 ± 0.23, p = 0.0036), but exhibited no significant inhibitory effect on tumor growth of MHCC-97H-CCN2-Sh cells (0.58 ± 0.06 vs. 0.55 ± 0.12, p = 0.5973) (Fig. 7c).