Univariate analysis revealed that tumor size (p = 0.026; p = 0.019), tumor number (p = 0.010; p = 0.007), and vascular invasion (p = 0.003; p = 0.002), as well as the expression levels of CCN2 (p = 0.001; p = 0.004) and LRP6 (p < 0.001; p < 0.001) were significantly associated with the post-operative OS and CCR of HCC patients. Here, CCN2 is linked to hepatocellular carcinoma.