When PLC-β2 was forcedly modulated in the entire MDA-MB-231 population, the number of CD133+/EpCAM+ cells significantly decreased, allowing to conclude that, in TNBC derived cells, this PLC isozyme may regulate the size of a cellular subset with high malignant potential, in terms of proliferation, invasion capability and surface expression of tumor stem cell markers. Here, PROM1 is linked to neoplasm.