In lung cancer, cells over-expressing both CD133 and EpCAM are more abundant than in normal tissues [32] and, in HCC derived cells, the CD133+/EpCAM+ sub-population shows increased colony-formation ability, drug-resistance, more spheroid formation by cultured cells and stronger tumorigenicity in NOD/SCID mice [26]. The gene discussed is PROM1; the disease is lung carcinoma.