The Chronic Renal Insufficiency Cohort (CRIC) investigators reported no association between intact-FGF23 levels and coronary/thoracic artery calcium in 1501 patients with earlier stages of CKD (mean eGFR of 47 ± 17 mL/min/1.73 m2), although this study was largely limited by a lag time of up to two years between the measurement of FGF23 and vascular imaging [29]. This evidence concerns the gene FGF23 and chronic kidney disease.