For instance, increased expression of inducible nitric oxide synthase which is involved in pathogenesis of asthma (Prado et al., 2011), ulcerative colitis (Dhillon et al., 2014) and inflammatory joints (McCartney-Francis, 1993) is a consequence of activation of NF-κB pathway in related cells including macrophages, colonic epithelial cells and synovial cells, respectively (Hatano et al., 2001). This evidence concerns the gene NFKB1 and asthma.