Interestingly, Aurora A, a downstream target of CDK1, was found to be phosphorylated by KCTD12 (Figure 4), a finding indicative of the existence of a positive regulatory loop in which KCTD12 facilitates the entry of cancer cells into M phase and promotes cancer cell proliferation by activating CDK1 signaling, and Aurora A phosphorylates KCTD12 at serine 243. The gene discussed is CDK1; the disease is cancer.