The results of this experiment showed that HeLa cells stably expressing wild-type KCTD12 formed larger tumors than cells expressing the vector control (607.1±146.8 vs 261.9±115.0 mm3; P<0.01); however, the stimulatory effects of KCTD12 on tumor growth were abrogated when serine 243 in KCTD12 was mutated (Figure 6d). Here, KCTD12 is linked to neoplasm.