KCTD12 and cancer: The results showed that overexpression of wild-type KCTD12 or the KCTD12 S200A mutant enhanced colony formation ability in HeLa cells, while overexpression of the KCTD12 S243A mutant failed to exert this effect (Figure 6a and Supplementary Figure S3), suggesting that phosphorylation of KCTD12 at serine 200 is not required for its effects on cancer cell proliferation.