A physical interaction of the CR3-region and the forkhead (FH) domain of FOXO3 with the TP53-DBD that affects the activity of both transcription factors has been demonstrated before.41, 42 To investigate, whether the identified mutations in the TP53-coding-region differentially affect FOXO3–TP53-interaction in NB, we performed co-immunoprecipitation experiments. The gene discussed is TP53; the disease is neuroblastoma.