For example, CD209 was reported to bind directly to mycobacteria-specific lipoglycan lipoarabinomannan presented on the surface of Mycobacterium tuberculosis, whereby mediating bacterial entry into DCs [34]; CD209 recognized and bound highly mannosylated envelope glycoprotein gp120 from HIV and promoted viral infection of CD4+ T lymphocytes [35]. Here, ITIH4 is linked to viral infectious disease.