Recently, we found that when rescued to the plasma membrane, Phe508del-CFTR also complexes with NHERF2 and LPA2 in CF bronchial epithelial cells (CFBEo−-Phe508del-CFTR cells) and in intestinal enterospheres developed from Phe508del−/− mice [29]. The gene discussed is LPAR2; the disease is cystic fibrosis.