Given the critical role of IL-8 and the IL-8 receptor signaling pathway in the pathogenesis of CF lung inflammation [51], we performed a proof-of-concept study to test whether CFTR-NHERF2-LPA2 complex regulates the IL-8 secretion from airway epithelial cells (CFBEo−-Phe508del-CFTR cells), thereby playing a role in the pathological cascade of excessive inflammation which fails to eradicate pulmonary pathogens in CF. Here, NHERF2 is linked to cystic fibrosis.