Finally, analysis of two functional ABCG1 SNPs (rs1378577, −134 T > G and rs1893590, −204 A > C in the promoter region) in 1320 French morbidly obese patients (BMI > 40 kg/m2) failed to detect any association between the 2 SNPs and homeostatic model assessment of insulin resistance (HOMA-IR) with or without adjustment for BMI [75]. The gene discussed is ABCG1; the disease is Insulin resistance.