Association of ABCG1 genotype with obesity was replicated in two independent populations composed of either 595 severely obese (35 < BMI < 40 kg/m2) or 216 diabetic obese (30 < BMI < 35 kg/m2) from the diabetes atorvastatin lipid intervention (DALI) subjects [75]. Here, ABCG1 is linked to obesity due to melanocortin 4 receptor deficiency.