However, investigation of the role of ABCG1 in mouse models as well as in human studies seems to indicate that the control of cellular lipid homeostasis operated by ABCG1 might play an important role in the wide spectrum of metabolic disorders, including obesity, diabetes and insulin resistance, which are risk factors for atherosclerosis and CVD. Here, ABCG1 is linked to obesity due to melanocortin 4 receptor deficiency.