ABCG1 and diabetes mellitus: In addition, although macrophage Abcg1 expression was consistently found reduced in diabetic mice or in response to stimuli relevant to diabetes (PUFA, glucose, AGEs), the impact of such a reduction on macrophage cholesterol efflux and potentially atherogenesis was not evaluated directly in experimental models in which Abcg1 expression may be manipulated (Abcg1 KO or Abcg1 KD).