Measurement of blood DNA methylation in Canadian Familial Hypercholesterolemia patients did not allow to establish any association between methylation levels at a single ABCG1 CpG site (CpGC3) and a prior history of CAD in a small subset of individuals (Non-CAD (n = 22) vs CAD (n = 22)) [81]. This evidence concerns the gene ABCG1 and familial hypercholesterolemia.