HMGCR and steatosis: Interestingly, and in coherence with observation in Abcg1-defiencient mice fed a high-cholesterol diet [62], an increased expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and sterol regulatory element-binding protein 2 (SREBP2) was also observed in liver from steatosis with or without NASH as compared to control biopsies [137].