Indeed, analysis of the effect of the functional ABCG1 SNP (rs1378577, T > G) on CAD severity in 109 Japanese men with CAD indicated that individuals homozygous for the T allele (TT) exhibited an increased risk of multi-vessel disease compared with single-vessel disease which was independent of any effect on plasma lipid levels [64]. Here, ABCG1 is linked to coronary artery disorder.