The association of DNA methylation at ABCG1 locus in whole blood DNA with plasma TG and HDL-C levels was replicated in several studies recapitulated in Table 1 which were conducted in the Botnia prospective study (cg06500161, TG, n = 258) [80], the Rotterdam study (cg06500161, TG and HDL-C, n = 1485) [78], the Framingham heart study (FHS) and prospective investigation of the vasculature in uppsala seniors study (PIVUS) (cg06500161, TG and HDL-C, cg27243685 and cg01176028, TG, n = 2036) [79] and in Canadian familial hypercholesterolemia patients (CpGC3, TG, HDL-C and TC, n = 98) [81]. The gene discussed is ABCG1; the disease is familial hypercholesterolemia.