In this studythe effect of grape seed extract (GSE) on triglyceride (TG), total cholesterol (TC), highdensity lipoprotein-cholestrol (HDL-C), low-density lipoprotein-cholestrol (LDL-C) andinterleukin-6 (IL-6) in PCOS Wistar rats were assessed. The gene discussed is IL6; the disease is polycystic ovary syndrome.