Occasionally, we also observed IgE+ dendritic cells (Freire et al., preliminary data), which are likewise known to express FcεRI.25 While there were highly significant differences between the eosinophilic infiltrates of HCs and BP, no major changes were found in the percentage of mast cells and eosinophils in BP and other inflammatory skin diseases, such as epidermolysis bullosa acquisita and dermatitis herpetiformis (Fig. S7; see Supporting Information). This evidence concerns the gene IGHE and inflammatory skin disease.