Nearly 50% of primary and almost 100% of metastatic prostate tumors have genetic alterations in the PI3K-AKT signaling pathway, mostly through loss of PTEN. 8However, while some of these tumors progress slowly, others rapidly spread beyond the site of origin and metastasize, implying that genetic alterations beyond this pathway may account for such different behaviors.7 Here, PTEN is linked to prostate neoplasm.