MFN2 and cancer: In this context, the use of modulators of ER–mitochondria tethers, such as the recently developed MFN2 inhibitors (174), could provide a relevant approach to further study cancer cell-intrinsic (such as the ER-to-mitochondria Ca2+ dependence for survival) and extrinsic (immunosurveillance mechanisms, inflammation and release of mitochondria-derived danger signals) processes that are modulated by ER–mitochondria contact sites.