On the other side of the coin, the phosphorylation state of IP3R3 is, directly or indirectly, modulated by the recruitment of different tumor suppressors, including the lipid phosphatase and negative regulator of Akt, the PTEN (132, 133), p53 (134) and the promyelocytic leukemia (PML) protein (135). This evidence concerns the gene TP53 and neoplasm.