Along with regulation of the phosphorylation state of IP3R and Ca2+ flux, the mTORc2/Akt complex controls mitochondrial metabolism and physiology, through the phosphorylation of the glycolytic enzyme hexokinase 2, thus promoting cancer cell’s aerobic glycolysis (Warburg effect) and preventing mitochondrial apoptosis (130, 131). The gene discussed is AKT1; the disease is cancer.