BCL2 and cancer: Beyond Akt and various antiapoptotic Bcl-2 family members including Bcl-2 and B-cell lymphoma-extra large (Bcl-XL), which are commonly overexpressed in a variety of cancers (140), have been proposed to suppress the IP3-mediated Ca2+-flux from ER to mitochondria by targeting the IP3Rs at the ER-mitochondria contact sites (141, 142).