PPARGC1A and fatty liver disease: We demonstrated that the inhibition of SMARCD1 expression induces cellular senescence in presenescent TIG-1 cells, and induces the accumulation of lipid droplets through the inactivation of PGC-1α-dependent transcription and suppressing FAO gene expression, consistent with the previous reports, showing that adenovirus-mediated expression of SMARCD1 stimulates FAO gene expression in hepatocytes and ameliorates hepatic steatosis in vivo9.