Relaxin circulating concentrations in women with T2DM have been found to be negatively correlated to pancreatic β-cells activity, but positively correlated to insulin sensitivity and to other factors that are closely related to pancreatic function and insulin sensitivity, like fasting circulating concentrations of insulin, total cholesterol and LDL cholesterol, or C peptide, suggesting that relaxin may protect against insulin resistance in women with T2DM (Szepietowska et al., 2008). This evidence concerns the gene INS and type 2 diabetes mellitus.