The acquired resistance of advanced PC to current treatment protocols (ADT, radiation, and chemotherapy) has been associated with apoptosis resistance of PC cells, especially based on an upregulation of the anti-apoptotic Bcl-2 family members (Gjertsen et al., 1998; Stein, 1999; Lebedeva et al., 2000; DiPaola et al., 2001). Here, BCL2 is linked to pachyonychia congenita.