Deep sequencing analysis on WT and AID-deficient mice by Liu et al. [133] furthermore showed that AID can act broadly throughout the genome in mouse B cells and deaminates numerous tumor-related genes including Myc, Pim1, Pax5, Ocab, H2afx, Rhoh, and Ebf1. In line with these data, the report by Staszewski et al. identified hundreds of reproducible, AID-dependent DSBs in mouse splenic B cells upon induction of CSR in culture. The gene discussed is AICDA; the disease is neoplasm.