However, as the molecular mechanism of one lncRNA may differ between different tissues and cell types, HNF1A‐AS1 might regulate osteosarcoma cell tumorigenesis and metastasis through different potential targets, and the specific target genes controlled by HNF1A‐AS1 in osteosarcoma require further studies to illustrate. The gene discussed is HNF1A; the disease is osteosarcoma.