CD4 and systemic sclerosis: Perivascular infiltrates composed of monocytes/macrophages and CD4+ T cells in nonlesional skin of SSc patients [63] as well as activated (CD69+) T cells and macrophages in affected skin at a higher extent within the first year from SSc onset [64] and of γ/δ T cells prominently in the early, edematous phases [65] are also described.