In a more recent work from the same group, the new criteria were applied and an increase in the serum levels of ICAM-1 among other circulating chemokines (CXCL8, CCL2) already in the preclinical group in comparison with the healthy control population was reported, with concentrations reaching the highest levels in the definite SSc subsets [57]. The gene discussed is ICAM1; the disease is systemic sclerosis.