Our results confirm in a more numerous and strategically stratified cohort the results of Valentini, showing a gradual increase of angiopoietin-2, CXCL16, E-selectin, and ICAM-1 from EaSSc to SSc without fibrotic features and reaching the highest levels in the fibrotic subsets, while levels of VEGF differed from HC only with regard to the fibrotic subsets. The gene discussed is SELE; the disease is systemic sclerosis.