Notably, among the numerous loci so far identified and replicated, peroxisome proliferator-activated receptor gamma (PPARG, antifibrotic and involved in adipogenesis [33]) and IL-12 receptor beta 1 (IL-12RB1, mediating IL-12-induced Th1 skewing and natural killer [NK] cell activation) are uniquely represented in SSc and not in SLE, rheumatoid arthritis (RA), primary biliary cirrhosis, or celiac disease [30], therefore advocating for preferential functional investigation and targeting in SSc. This evidence concerns the gene IL12RB1 and systemic sclerosis.