ICAM1 and systemic sclerosis: Our results confirm in a more numerous and strategically stratified cohort the results of Valentini, showing a gradual increase of angiopoietin-2, CXCL16, E-selectin, and ICAM-1 from EaSSc to SSc without fibrotic features and reaching the highest levels in the fibrotic subsets, while levels of VEGF differed from HC only with regard to the fibrotic subsets.