Given that blockade of NLRP3 inflammasome could delay tumorigenesis in SCCHN mice by reducing the production of IL-1β, and the stimulation on NLRP3 inflammasome from early tumor is less than advanced tumor, which might account for the decreased expression of NLRP3 and pro-Caspase-1. Here, IL1B is linked to head and neck squamous cell carcinoma.