In addition, our western blot results showed that NLRP3, Caspase-1, IL-18 and IL-1β were highly expressed in the Tgfbr1/Pten 2cKO mice SCCHN tumor lysates compared with control wild type tongues, and the expression of BMI1, ALDH1 and CD44 were consistent with NLRP3 inflammasome (Fig. 2e and f). The gene discussed is IL18; the disease is head and neck squamous cell carcinoma.