BRCA2 and breast cancer: Anytime use of diagnostic chest X-rays before the age of 50 years in women carrying the BRCA1/2 gene mutations is associated with an increased risk of breast cancer (BRCA1 OR = 1.16; 95% CI = .64–2.11; BRCA2 OR = 1.22; 95% CI = .62–2.42) [797].