Similarly, Doherty et al. demonstrated in both MCF-7 cells and in mammary glands from neonatally exposed mice that either BPA or diethylstilbestrol (DES) treatment led to a 2–3 fold increase in expression of the breast cancer associated histone methyltransferase, Enhancer of Zeste Homolog 2 (EZH2) mRNA expression and subsequent EZH2 synthesis. Here, EZH2 is linked to breast carcinoma.