In addition, we studied the role of SUR1-TRPM4 channels in cultured primary astrocytes activated by tumor necrosis factor (TNF) plus interferon γ (IFNγ), and we analyzed demyelinating lesions from MS patients to ascertain whether SUR1-TRPM4 channels are expressed by perilesional astrocytes in humans with MS. Here, ABCC8 is linked to myeloid sarcoma.