Fourth, although beyond the scope of this study, determining the potential involvement of SUR1-TRPM4 in preactive white matter lesions with “normal appearing white matter” will be important to elucidate the role, if any, of SUR1-TRPM4 in MS pathogenesis, including the relation between astrocytic SUR1-TRPM4 and the microglial clusters that comprise the earliest identified abnormality in MS [58, 59]. This evidence concerns the gene ABCC8 and myeloid sarcoma.