Among above three subnetworks, 15 genes (FZD3, KCNA4, RAD21, KIAA1109, LYST, SCN11A, AKAP6, PCDHA13, ADAMTSL3, PCDH11X, MAP2K4, COL11A1, FBN1, NAV3 and FN1), 7 miRNAs (hsa-miR-25, hsa-miR-29a, hsa-miR-34a, hsa-let-7c, hsa-let-7e, hsa-miR-27b, hsa-miR-27a) and 8 TFs (FOXG1, TCF12, FOXJ2, MYCN, TFEB, CREB1, RUNX1, CBFB) participated in all subnetworks simultaneously, which suggested that they might act extensively in the CRC regulation. Here, KCNA4 is linked to colorectal carcinoma.