In these TF-FFLs, there were 115 edges (55 TF-gene pairs, 53 TF-miRNA pairs, and 7 miRNA-gene pairs) and 58 unique nodes (45 human TFs, 7 CRC-related genes, and 6 CRC-related miRNAs) Additional file 2: Table S6). Here, TF is linked to colorectal carcinoma.