Among above three subnetworks, 15 genes (FZD3, KCNA4, RAD21, KIAA1109, LYST, SCN11A, AKAP6, PCDHA13, ADAMTSL3, PCDH11X, MAP2K4, COL11A1, FBN1, NAV3 and FN1), 7 miRNAs (hsa-miR-25, hsa-miR-29a, hsa-miR-34a, hsa-let-7c, hsa-let-7e, hsa-miR-27b, hsa-miR-27a) and 8 TFs (FOXG1, TCF12, FOXJ2, MYCN, TFEB, CREB1, RUNX1, CBFB) participated in all subnetworks simultaneously, which suggested that they might act extensively in the CRC regulation. This evidence concerns the gene MAP2K4 and colorectal carcinoma.