Among above three subnetworks, 15 genes (FZD3, KCNA4, RAD21, KIAA1109, LYST, SCN11A, AKAP6, PCDHA13, ADAMTSL3, PCDH11X, MAP2K4, COL11A1, FBN1, NAV3 and FN1), 7 miRNAs (hsa-miR-25, hsa-miR-29a, hsa-miR-34a, hsa-let-7c, hsa-let-7e, hsa-miR-27b, hsa-miR-27a) and 8 TFs (FOXG1, TCF12, FOXJ2, MYCN, TFEB, CREB1, RUNX1, CBFB) participated in all subnetworks simultaneously, which suggested that they might act extensively in the CRC regulation. The gene discussed is FBN1; the disease is colorectal carcinoma.