APLN and neoplasm: Hypoxia play a critical role in the pathogenesis of a broad array of disease especially those in which the vasculature is a component, therefore we used the Apln-CreERT:mT/mG mice to observe the sprouting angiogenesis pattern in hypoxia retina and tumor model, providing evidence for future molecular mechanisms study of sprout angiogenesis and find therapeutic target for angiogenesis-related diseases.